By F.J. Dixon, Henry G. Kunkel (Eds.)
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And Putnam, F. W. (1970). Nature (London) 227, 1318. Koo, P. , and Cebra, J. J. (1974). Biochemistry 13, 184. Kuettner, M. , Wang, A. , and Nisonoff, A. (1972). J. E x p . Med. 135, 579. Kunkel, H. , and Williams, R. C. (1963). Science 140, 1218. VARIABLE REGIONS, IDIOTYPY, AM) COMBINING SITE 39 Kunkel, H. , Joslin, F. , Winchester, R. , and Capra, J. D. (1973). J. Erp. Med. 137, 311. Kunkel, H. , Winchester, R. , Joslin, F. , and Capra, J. D. (1974). J. Erp. Med. 139, 128. Leon, M. , Young, N.
Although immunoglobulins of the donor type were detected in recipients, the bulk of antibody contained the allotypic markers of the recipient, indicating that the antibodies were most probably synthesized by host cells. Antiidiotypic antisera directed against donor antibody reacted with a great proportion of recipient antibodies. Xmmunofluorescence studies showed that molecules bearing allotypic markers of the recipient were associated with idiotypic determinants of donors. These data imply that the synthesis of the V region of the heavy chain may be under the control of more than a single gene.
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Advances in Immunology, Vol. 20 by F.J. Dixon, Henry G. Kunkel (Eds.)